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Possible adverse effects are, with i.m.injection: persistent pain at the injection site and skin discoloration; with i.v. injection: flushing, hypotension, anaphylactic shock. Upon vascular injury, the coagulation system is activated: thrombocytes and fibrin molecules coalesce into a “plug” (p. 148) that seals the defect and halts bleeding (hemostasis).
This difference may be due to the higher impulse frequency and longer action potential duration in nociceptive, as opposed to motor, fibers. Alternatively, it may be related to the thickness of sensory and motor nerves, as well as to the distance between nodes of Ranvier. In saltatory impulse conduction, only the nodal membrane is depolarized. |
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